Targeted delivery of colloids by swimming bacteria

Flocculation of bacteria by hydrophilic colloids.

Bacteria, like many colloids, are generally considered to be negatively charged at a neutral pH. In many cases, bacteria behave as typical hydrophilic colloids and are not precipitated nor flocculated by merely reducing the surface charges to zero (Lamanna and Mallette, 1953). When this is the situation, it is necessary to add dehydrating agents or specific antibodies to obtain flocculation. Ob...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Formulation of temozolomide by folic acid-conjugated tri-block copolymer nanoparticles for targeted drug delivery

Introduction: Glioblastoma multiforme (GBM) is the most frequent primary malignant tumor of the brain. But, the treatment of GBM is one of the most problems in cancer therapy because of poor drug penetration across the blood-brain barrier (BBB). Targeting drug delivery system and conjugating targeting moieties was recognized to overcome the poor penetration of chemotherapy drug...

Hydrodynamic Trapping of Swimming Bacteria by Convex Walls.

Swimming bacteria display a remarkable tendency to move along flat surfaces for prolonged times. This behavior may have a biological importance but can also be exploited by using microfabricated structures to manipulate bacteria. The main physical mechanism behind the surface entrapment of swimming bacteria is, however, still an open question. By studying the swimming motion of Escherichia coli...